Genetically predicted benign prostate hyperplasia causally affects prostate cancer: a two-sample Mendelian randomization.

ABSTRACT:

Background

Benign prostate hyperplasia (BPH) and prostate cancer (PCa) share several similarities, including androgen dependency and parallel increases in prevalence with age. Although PCa lags by 15-20 years, no causal association has been identified between BPH and PCa. To investigate the potential causal links between BPH and PCa, this study was performed in a two-sample Mendelian randomization (MR) design.

Methods

We retrieved single-nucleotide polymorphisms (SNPs) associated with BPH from genome-wide association studies (GWAS), which were obtained from the Integrative Epidemiology Unit database, and conducted a two-sample MR analysis to explore the causal relationship between BPH and PCa. The exposure dataset included 13,118 BPH cases and 72,799 controls, while the outc

SUBMITTER: Huang H 

PROVIDER: S-EPMC11986520 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature