Exploration of the plasma proteomic profile of patients at risk of thromboembolic events.

ABSTRACT:

Background

The elevated health burden of thromboembolic events necessitates development of blood-based risk monitoring tools.

Objectives

We explored the potential of mass spectrometry-based plasma proteomics to provide insights into underlying plasma protein signatures associated with treatment and occurrence of thromboembolic events.

Methods

Utilizing a high-throughput, data-independent acquisition, discovery-based proteomics workflow, we analyzed 434 plasma proteomes from different groups of individuals with elevated risk of thromboembolic events, including individuals I) on vitamin K antagonists (VKAs; n = 130), II) with a prior venous thromboembolism (n = 10), III) with acute cerebral venous sinus thrombosis (n = 10, and IV) with SARS-CoV-2 in

SUBMITTER: Smit ER 

PROVIDER: S-EPMC11986537 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature