Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database.

ABSTRACT:

Background

Fluid resuscitation is a standard intervention for patients with sepsis, however, the ideal timing for initiating fluid deresuscitation has not been well established. This study examines the prognostic impact of early versus delayed initiation of loop diuretics in patients with sepsis.

Methods

Data for this analysis were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients diagnosed with sepsis were categorized into two groups based on the timing of loop diuretic administration: an early group (within 48 hours of diagnosis) and a late group (after 96 hours).

Results

A total of 8,518 patients with sepsis were included in this study. Of these, 4,485 patients received loop diuretics within the first 48 hours (early gro

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11986544 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature