Exploring the role of glycolysis in the pathogenesis of erectile dysfunction in diabetes.

ABSTRACT:

Background

Diabetes mellitus-related erectile dysfunction (DMED) is characterized by complicated pathogenesis and unsatisfactory therapeutic remedies. Glycolysis plays an essential role in diabetic complications and whether it is involved in the process of DMED has not been expounded. The aim of this study was to investigate the genetic profiling of glycolysis and explore potential mechanisms for DMED.

Methods

Glycolysis-related genes (GRGs) and gene expression matrix of DMED were obtained from the molecular signatures database and gene expression omnibus dataset. Differentially expressed analysis and support vector machine-recursive feature elimination (SVM-RFE) method were both used to obtain hub GRGs. Interactive network and functional enrichment analyses were performed t

SUBMITTER: Deng W 

PROVIDER: S-EPMC11986553 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature