Protein post-translational modification crotonylation of TXN and GLO1 in artery and vein grafts for coronary artery surgery.

ABSTRACT: A key problem in coronary artery bypass grafting (CABG) is the lower long-term patency of the saphenous vein (SV) compared to internal thoracic artery (ITA). The potential strategies to improve the long-term patency of the vein graft include developing drugs to block unfavorable pathways in the vein and even to change the protein structure of the vein towards arterial structure. It is therefore important to understand the differences of the protein structure between arterial and venous grafts. Using post-translational modification (PTM) proteomics, we systematically investigated differences between ITA and SV with regard to a vascular stenosis-related PTM crotonylation. Crotonylome and PTM crotonylation in paired ITA and SV segments (n = 150) from patients undergoing CABG surgery were perf

SUBMITTER: Sun WT 

PROVIDER: S-EPMC11986619 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature