Amygdala subregion volumes and apportionment in preadolescents - Associations with age, sex, and body mass index.

ABSTRACT: The amygdala, a key limbic structure, is critical to emotional, social, and appetitive behaviors that develop throughout adolescence. Composed of a heterogeneous group of nuclei, questions remain about potential differences in the maturation of its subregions during development. In 3953 9- and 10-year-olds from the Adolescent Brain Cognitive Development℠ Study, the CIT168 Atlas was used to segment nine amygdala subregions. Linear mixed-effects models were used to examine the effects of age, sex, pubertal stage, and body mass index z-score (BMIz) on subregion volumes and their relative apportionment within the amygdala. Distinct associations were observed between age, sex, and BMIz with whole amygdala volume, subregion volumes, and subregion apportionment. Pubertal stage was not related to

SUBMITTER: Overholtzer LN 

PROVIDER: S-EPMC11986629 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature