Efficacy and safety of different forms of ablation therapies and antiarrhythmic drugs in atrial fibrillation: a systematic review and network meta-analysis of randomized clinical trials.

ABSTRACT:

Background

This Bayesian network meta-analysis (NMA) was conducted to compare the efficacy and safety of ablations and antiarrhythmic drugs (AADs) to determine the optimal treatment choice for atrial fibrillation (AF).

Methods

We searched PubMed, Embase, Web of Science, and Cochrane Library from their inception to December 15, 2024, for relevant randomized controlled trials (RCTs). The risk of bias assessment tool developed by the Cochrane Collaboration Network was utilized to evaluate the risk of bias. The main outcomes were AF recurrence, adverse events, and all-cause death. A Bayesian NMA was conducted based on the collected data.

Results

In total, 65 RCTs (n=17,770) comparing four ablations [cryoablation (CBA), laser balloon ablation (LBA), radiofrequency ablation

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11986745 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature