Tetramethylpyrazine mitigates lipopolysaccharide-induced acute lung injury by inhibiting the HMGB1/TLR4/NF-κB signaling pathway in mice.

ABSTRACT:

Background

Tetramethylpyrazine (TMP) possesses anti-inflammatory and antioxidant properties and plays a crucial role in mitigating acute lung injury (ALI). However, the specific underlying mechanisms remain elusive. High mobility group box 1 (HMGB1), a pro-inflammatory factor, can bind to Toll-like receptor 4 (TLR4), activating downstream signaling pathways, which in turn activate nuclear factor kappa-B (NF-κB). This study aims to explore the preventive effects of TMP on lipopolysaccharide (LPS)-induced ALI and its influence on the HMGB1/TLR4/NF-κB signaling pathway.

Methods

C57BL/6 mice were randomly divided into a control group (CON group), a model group (LPS group), a heparin (Hep) group, and a TMP group. In the model group, mice received an initial intraperitoneal inject

SUBMITTER: He X 

PROVIDER: S-EPMC11986780 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature