Relationship between the expression of striated preferentially expressed gene (<i>SPEG</i>) and the development of atrial fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is a heart rate disorder associated with a high disability rate. A number of genes involved in core coding are also implicated in the development of AF. The striated preferentially expressed gene (SPEG) is a newly discovered gene related to the pathogenesis of AF. It promotes disease development by participating in fibrosis and abnormal ion channel function. In this study, the high-risk genes of AF disease were screened by bioinformatics analysis, and the gene polymorphism and gene expression of AF related genes were further analyzed.

Methods

(I) SPEG was selected as the core gene of AF according to gene intersection, protein-protein interaction (PPI), and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)

SUBMITTER: Wei J 

PROVIDER: S-EPMC11986788 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature