Genomic characterization of <i>Streptococcus pneumoniae</i> isolates obtained from carriage and disease among paediatric patients in Addis Ababa, Ethiopia.

ABSTRACT: Background and aims. Despite the introduction of pneumococcal conjugate vaccines (PCVs), Streptococcus pneumoniae still remains an important cause of morbidity and mortality, especially among children under 5 years in sub-Saharan Africa. We sought to determine the distribution of serotypes, lineages and antimicrobial resistance of S. pneumoniae from carriage and disease among children presenting to health facilities, 5-6 years after the introduction of PCV10 in Ethiopia.Methods. Whole-genome sequencing (WGS) was performed on 103 S. pneumoniae (86 from nasopharyngeal swabs, 4 from blood and 13 from middle ear discharge) isolated from children aged <15 years at 3 healthcare facilities in Addis Ababa, Ethiopia, from September 2016 to August 2017. Using the W

SUBMITTER: Negash AA 

PROVIDER: S-EPMC11986848 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature