Bidirectional Mendelian Randomization Study Identifies No Genetic Link Between Psoriasis and Diabetes.

ABSTRACT: Epidemiological studies proposed a bidirectional link between psoriasis (Ps) and diabetes mellitus (DM); their causal relationship remains inadequately explored. We obtained summary statistics of genome-wide association analyses for Type 1 diabetes mellitus (T1DM), Type 2 diabetes mellitus (T2DM), and Ps from individuals of European ancestry by accessing the UK Biobank and FinnGen datasets. Inverse-variance weighted (IVW) method was utilized as the primary method. Additional analyses included debiased IVW (dIVW), constrained maximum likelihood with model averaging, robust adjusted profile score, Mendelian randomization (MR)-Egger, weighted median, and weighted mode. Moreover, sensitivity tests were conducted, including Cochran's Q, MR pleiotropy residual sum, and outlier analyses. E

SUBMITTER: Li J 

PROVIDER: S-EPMC11986917 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature