Association Between ABCG1/TCF7L2 and Type 2 Diabetes Mellitus: An Intervention Trial Based on a Case-Control Study.

ABSTRACT: Background and Objective: Type 2 diabetes mellitus (T2DM) is the result of both genetic and environmental factors. Environmental factors may contribute to the occurrence and development of T2DM by influencing epigenetic modification. The objective of this study was to explore the potential functions of two SNP-CG sites (rs7901695 of TCF7L2 and cg06500161 of ABCG1) that are most strongly associated with T2DM. Given that Uyghur population has been less studied, we conducted an intervention trial in Uyghur people to provide evidence for personalized health management of T2DM in them. Methods: From May to July 2022, 320 patients with T2DM and 332 patients without T2DM were treated with dietary pagoda-based health education intervention. The demographic data were collected before

SUBMITTER: Su Y 

PROVIDER: S-EPMC11986924 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature