Target of rapamycin signaling regulates starch degradation via α-glucan water dikinase in a unicellular red alga.

ABSTRACT: Target of rapamycin (TOR) signaling pathways are major regulators of starch accumulation in various eukaryotes. However, the underlying molecular mechanisms of this regulation remain elusive. Here, we report the role of TOR signaling in starch degradation in the unicellular red alga Cyanidioschyzon merolae. Reanalysis of our previously published phosphoproteome data showed that phosphorylation of the serine residue at position 264 of a protein similar to α-glucan water dikinase (CmGWD), a key regulator of starch degradation, was not increased by rapamycin treatment. In the CmGWD knockout strain, starch content increased and starch phosphorylation decreased, indicating that CmGWD is a functional GWD. CmGWD-dependent starch degradation under dark conditions was alleviated by rapamycin treatm

SUBMITTER: Komiya S 

PROVIDER: S-EPMC11986951 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature