Spontaneous Generation of an Endogenous RORγt Agonist.

ABSTRACT: The transcription factor RORγt regulates the development of Th17 cells and their inflammatory cytokine IL-17─a pathway that can both clear bacterial pathogens and drive autoimmune diseases. An endogenous RORγt agonist with a noncanonical structure, a lysophosphatidylethanolamine (1-18:1-LPE or 1), was recently identified, and its identity both increases our understanding of immune regulation and creates options for therapeutic intervention. Compound 1 could be formed directly through enzymatic cleavage of a suitable phosphatidylethanolamine (PE) by a phospholipase A2 (PLA2) or by "triggering" of a suitable plasmalogen with accompanying 1,2-acyl migration from the sn-2 to sn-1 positions of glycerol. This study illustrates the plausibility of a plasmalogen-based p

SUBMITTER: Ma XC 

PROVIDER: S-EPMC11987011 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature