Polymorphic ROYalty: The 14th ROY Polymorph Discovered via High-Throughput Crystallization.

ABSTRACT: Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation. Polymorphs often exhibit differing physical properties, and are therefore particularly important in the development of materials and pharmaceuticals. However, gaining a thorough understanding of the solid-state landscape of a molecule requires exhaustive experimental screening of crystallization conditions, a particular challenge when using classical crystallization methods. We show that high-throughput Encapsulated Nanodroplet Crystallization (ENaCt) can enable the rapid and efficient exploration of the solid-state landscape of highly polymorphic molecules, through an in-depth study of 5-methyl-2-(

SUBMITTER: Weatherston J 

PROVIDER: S-EPMC11987018 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature