Osteosarcoma Exosome Priming of Primary Human Lung Fibroblasts Induces an Immune Modulatory and Protumorigenic Phenotype.

ABSTRACT:

Abstract

Osteosarcoma (OS) is the most common malignant bone cancer. Thirty to forty percent of all patients with OS develop tumor recurrence, almost exclusively in the form of lung metastasis, which is associated with a dismal 20% 5-year survival rate. Cancer-associated fibroblasts are a critical cell type within the lung tumor microenvironment that promote immune suppression, drug resistance, and tumor cell survival. Prior work shows tumor cells can co-opt fibroblasts to a protumorigenic phenotype via exosome-mediated intercellular communication. Currently, the mechanisms by which OS exosomes modulate resident lung fibroblast (LF) function have not been evaluated. To investigate this, we isolated exosomes from a panel of six OS cell lines. We assessed the uptake and response of h

SUBMITTER: Palmer EP 

PROVIDER: S-EPMC11987067 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature