Tacrolimus versus cyclosporine immunosuppression in lung transplantation: a systematic review and meta-analysis.

ABSTRACT:

Background

The relative efficacy of calcineurin inhibitors tacrolimus and cyclosporine in lung transplantation remains unclear. To clarify, we conducted a systematic review and meta-analysis.

Methods

We searched through EMBASE, MEDLINE and Cochrane CENTRAL until 23 October 2023 for randomised trials comparing tacrolimus with cyclosporine in lung transplant recipients. Data extraction and bias risk assessment were done independently. Analyses included random effects pairwise meta-analysis and trial sequential analysis, with GRADE system for evidence certainty.

Results

We found four eligible trials totalling 662 patients. Tacrolimus significantly reduces the risk of chronic lung allograft dysfunction (RR 0.46, high certainty) and likely decreases acute rejection risk (R

SUBMITTER: Pitre T 

PROVIDER: S-EPMC11987090 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature