Developing physical Activity and Sedentary behaviour thresholds for the Secondary prevention of Heart disease (DASSH): a cohort mortality survival tree analysis.

ABSTRACT:

Background

The dose-response relationship between physical activity and sedentary behaviour (SB) with mortality in people with coronary heart disease (CHD) is unclear. The aim was to identify moderate-to-vigorous physical activity (MVPA) and SB thresholds for mortality risk.

Methods

This prospective cohort study comprised Australian participants aged ≥ 45 years with self-reported CHD (2006-2020). Self-reported MVPA (min/wk) and SB (hr/day) were the exposures. Cardiac and all-cause mortality were the main outcomes. Survival regression trees identified MVPA and SB thresholds influencing mortality survival rate. Cox regression models and the C-statistic were used to examine the thresholds, comparing them to public health guidelines.

Results

The cohort included 40,156 par

SUBMITTER: Freene N 

PROVIDER: S-EPMC11987228 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature