Tissue factor, factor VIII and IX in microvesicle-induced thrombosis and tumor growth of pancreatic cancer.

ABSTRACT:

Background

Tissue factor (TF)-rich cancer microvesicles are correlated with thrombosis risk. Intrinsic coagulation factors are also associated with the risk of thrombosis in cancer patients. This study explored the roles of pancreatic cancer-derived microvesicles and intrinsic factors in thrombogenesis.

Methods

Human pancreatic cancer cell lines rich in TF (AsPC-1-TF^high, MIAPaCa-2-TF^high) or poor in TF [AsPC-1-TF^KO(knockout) and MIAPaCa-2-TF^low] were generated for microvesicle preparation and injected into coagulation-defective mice. Inferior vena cava (IVC) clots and lung thrombosis were evaluated. Immunodeficient hemophilia A (NSG-HA) mice were orthotopically injected with the cells mentioned above, and the tumor and IVC clot we

SUBMITTER: Chou SC 

PROVIDER: S-EPMC11987238 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature