Atrophy trajectories in Alzheimer's disease: how sex matters.

ABSTRACT:

Introduction

Longitudinal subtypes in Alzheimer's disease (AD) have been identified based on their distinct brain atrophy trajectories, encompassing mediotemporal and cortical pathways. These subtypes include minimal atrophy, limbic predominant, limbic predominant plus, diffuse atrophy and hippocampal sparing. The impact of sex on the progression of these subtypes remains a crucial area of investigation.

Methods

We analysed MRI data from 320 amyloid-β positive individuals with AD from three international cohorts (ADNI, J-ADNI and AIBL). Longitudinal clustering was conducted to identify atrophy trajectories over eight years from the clinical disease onset, with separate trajectories delineated for women and men.

Results

Women consistently exhibited earlier hippocampal

SUBMITTER: Inguanzo A 

PROVIDER: S-EPMC11987288 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature