Early new bone formation in ovine intramuscular defects: comparison between different silicate-containing calcium phosphate synthetic bone grafts.

ABSTRACT:

Background

The property of in vivo osteoinductivity (OI) has been reported in synthetic calcium phosphates bone grafts, including silicate-containing calcium phosphates in different animal intramuscular defect models. However, most studies that have evaluated osteoinductivity in these models only focus on the formation of new bone at only one endpoint, typically 12 weeks, and without reporting evidence of graft resorption.

Methods

Three clinically available silicate-containing calcium phosphate bone graft substitutes were characterised and then implanted into an ovine intramuscular defect model for 6 or 12 weeks to assess their bone forming potential. Bone formation was evaluated with radiographs, micro-CT (µCT) and qualitative histology.

Result

The main physical/chem

SUBMITTER: Gibson IR 

PROVIDER: S-EPMC11987333 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature