A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia.

ABSTRACT:

Background

About 40% of relapsed or non-responder tumors exhibit therapeutic resistance in the absence of a clear genetic cause, suggesting a pivotal role of intracellular communication. A deeper understanding of signaling pathways rewiring occurring in resistant cells is crucial to propose alternative effective strategies for cancer patients.

Methods

To achieve this goal, we developed a novel multi-step strategy, which integrates high sensitive mass spectrometry-based phosphoproteomics with network-based analysis. This strategy builds context-specific networks recapitulating the signaling rewiring upon drug treatment in therapy-resistant and sensitive cells.

Results

We applied this strategy to elucidate the BCR::ABL1-independent mechanisms that drive relapse upon the

SUBMITTER: Bica V 

PROVIDER: S-EPMC11987405 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature