The nonlinear correlation of neutrophil-lymphocyte ratio on 1-year mortality risk in patients with severe acute heart failure.

ABSTRACT:

Background

This retrospective cohort study was designed to examine the relationship between the neutrophil-lymphocyte ratio (NLR) and the 1-year risk of death in patients with acute heart failure (AHF) in the intensive care unit (ICU).

Methods

We retrospectively analyzed 1,176 patients with AHF from the MIMIC-IV database. Cox regression was used to evaluate the relationship between NLR and 1-year mortality risk after adjusting for covariates. Nonlinear associations and optimal NLR cutoff values were determined using restricted cubic splines. Propensity score matching was used to eliminate imbalances in the baseline confounders. Kaplan-Meier survival analysis further confirmed the correctness of the threshold. The ROC was used to evaluate the diagnostic accuracy of the NLR fo

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11987478 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature