Effects of dopamine receptor antagonists and radiation on mouse neural stem/progenitor cells.

ABSTRACT:

Background

Dopamine receptor antagonists have recently been identified as potential anti-cancer agents in combination with radiation, and a first drug of this class is in clinical trials against pediatric glioma. Radiotherapy causes cognitive impairment primarily by eliminating neural stem/progenitor cells and subsequent loss of neurogenesis, along with inducing inflammation, vascular damage, and synaptic alterations. Here, we tested the combined effects of dopamine receptor antagonists and radiation on neural stem/progenitor cells.

Methods

Using transgenic mice that report the presence of neural stem/progenitor cells through Nestin promoter-driven expression of EGFP, the effects of dopamine receptor antagonists alone or in combination with radiation on neural stem/progenito

SUBMITTER: He L 

PROVIDER: S-EPMC11987595 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature