Genome-wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank.

ABSTRACT:

Introduction

Chronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear. This study aimed to identify single-nucleotide polymorphisms associated with developing chronic postsurgical pain after abdominal surgery, one of the most common types of surgery.

Methods

A genome-wide association study was performed on 27,603 patients from the UK Biobank who underwent abdominal surgery. The robustness of identified loci was validated by split-half validation analysis. Functionally related top loci were selected for expression validation in clinical samples of adhesions from patients with and

SUBMITTER: Li S 

PROVIDER: S-EPMC11987778 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature