Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction.

ABSTRACT:

Introduction

High mechanical power is associated with mortality in patients who are critically ill and require invasive ventilation. It remains uncertain which components of mechanical power - volume, pressure or rate - increase mechanical power the most.

Methods

We conducted a post hoc analysis of a database containing individual patient data from three randomised clinical trials of ventilation in patients without acute respiratory distress syndrome. The primary endpoint was mechanical power. We used linear regression; double stratification to create subgroups of participants; and mediation analysis to assess the impact of changes in volumes, pressures and rates on mechanical power.

Results

A total of 1732 patients were included and analysed. The median (IQR [range])

SUBMITTER: Buiteman-Kruizinga LA 

PROVIDER: S-EPMC11987796 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature