Positive Prognostic Overall Survival Impacts of Methylated <i>TGFB2</i> and <i>MGMT</i> in Adult Glioblastoma Patients.

ABSTRACT: (1) Background: Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor in adults, constituting 45.6% of tumors. We explored the impact of gene methylation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) and the Transforming Growth Factor Beta (TGFB) gene complex using the TCGA dataset for GBM patients. (2) Methods: We implemented a multivariate Cox proportional hazards model to directly compare hazard ratios for TGFB1/2/3 and MGMT methylation in relation to OS, considering male versus female, age at diagnosis, and age interactions with TGFB2 gene methylation and sex variables. Reactome analysis was performed to identify enriched pathways negatively correlated with TGFB2 methylation. (3) Results: The GBM patients ha

SUBMITTER: Qazi S 

PROVIDER: S-EPMC11987947 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature