Low WT1 Expression Identifies a Subset of Acute Myeloid Leukemia with a Distinct Genotype.

ABSTRACT: Background: Wilms' tumor gene 1 (WT1) is a critical player in acute myeloid leukemia (AML), often serving as a biomarker for measurable residual disease (MRD). The WT1 gene is overexpressed in the majority of AML cases at diagnosis, with apparently no correlation with prognosis, and in the meantime, its role in patients with low-level expression is still undefined. This study investigates the mutational landscape and clinical outcomes of AML patients with low WT1 expression at diagnosis. Methods: We analyzed 34 AML patients with low WT1 expression (WT1/ABL1 < 250) diagnosed and treated from 2013 to 2017 at three institutions. Next-generation sequencing (NGS) was employed to investigate the mutational status of 32 genes commonly mutated in AML. The presenc

SUBMITTER: Rondoni M 

PROVIDER: S-EPMC11988028 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature