A Retrospective Analysis of Ambiguous Spitz Tumors Using Next-Generation Sequencing.

ABSTRACT: Background: Spitz tumors (STs) are a diverse group of melanocytic lesions that range from benign to malignant. STs pose significant classification challenges due to overlapping histological and immunohistochemical (IHC) features among the STs with different malignant potential. This study aimed to assess the diagnostic value of a melanoma-specific next-generation sequencing (NGS) panel (MelArray) combined with IHC analysis to improve the assessment of diagnostically challenging ST cases. Methods: Patients with STs and available MelArray results were included in this retrospective analysis. Molecular analysis (genetic alterations, tumor mutational burden (TMB), and copy number variations (CNV)), clinical data (demographics and clinical course), and IHC data (scores for markers

SUBMITTER: Teufer M 

PROVIDER: S-EPMC11988030 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature