Second line advanced or metastatic non-small cell lung cancer treatment after chemo-immunotherapy: a retrospective study.

ABSTRACT:

Background

With the shift to immunotherapy (IO) in first-line (1L) treatment for patients with advanced non-small cell lung cancer (aNSCLC), this study aims to describe second-line (2L) treatment patterns and outcomes.

Methods

This retrospective study examined 2L outcomes in patients with stage IIIB-IV, epidermal growth factor receptor (EGFR)-/anaplastic lymphoma kinase (ALK) wild-type aNSCLC who started 1L therapy between 2016 and 2019 and received subsequent 2L therapy. Follow-up continued through November 2020. Subgroups included: 2L IO, 2L non-IO, and IO re-challenge (1L and 2L).

Results

A total of 194 patients initiated 2L therapy; 93 received IO (12 also in 1L), and 101 did not. For IO and non-IO, respectively: overall response rate (ORR) was 28.0% and 25.7%; me

SUBMITTER: Bazhenova L 

PROVIDER: S-EPMC11988219 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature