<i>Helicobacter pylori</i> γ-glutamyltransferase is linked to proteomic adaptions important for colonization.

ABSTRACT: Helicobacter pylori γ-glutamyltransferase (gGT) is a virulence factor that promotes bacterial colonization and immune tolerance. Although some studies addressed potential functional mechanisms, the supportive role of gGT for in vivo colonization remains unclear. Additionally, it is unknown how different gGT expression levels may lead to compensatory mechanisms ensuring infection and persistence. Hence, it is crucial to unravel the in vivo function of gGT. We assessed acid survival under conditions mimicking the human gastric fluid and elevated the pH in the murine stomach prior to H. pylori infection to link gGT-mediated acid resistance to colonization. By comparing proteomes of gGT-proficient and -deficient isolates before and after infecting mice, we investiga

SUBMITTER: Fuchs S 

PROVIDER: S-EPMC11988274 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature