The Probiotic Strain <i>Clostridium butyricum</i> TO-A Produces Butyrate by Utilizing Lactate and Acetate.

ABSTRACT: Lactate-utilizing bacteria (LUB) are intestinal bacteria that produce butyrate from lactate and acetate, key metabolites in the gut. As LUB help maintain lactate and butyrate concentrations in the intestinal tract, they are promising probiotic candidates. Clostridium butyricum TO-A (CBTOA) has reportedly been effective in treating various gastrointestinal issues in humans and animals. Although CBTOA is known to increase intestinal butyrate levels, it is unclear how it utilizes lactate and acetate, similar to LUB, to produce butyrate. We investigated lactate utilization-related genes in CBTOA and examined the relationship between lactate and acetate utilization and butyrate production using peptone-yeast medium supplemented with D-lactate, L-lactate, and/or acetate. This study demons

SUBMITTER: Honda S 

PROVIDER: S-EPMC11988312 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature