Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs Impact <i>Caenorhabditis elegans</i> Development and Reproductive Behavior.

ABSTRACT: Designer drugs like 2C-I and 25I-NBOMe have emerged as potent psychoactive substances, with several reports linking their consumption to severe poisoning and fatalities. However, there is limited information on their toxicity, particularly in in vivo models. In this manuscript, we evaluate the survival, developmental, and reproductive impact of these designer drugs on the model organism Caenorhabditis elegans (C. elegans). For this purpose, adult worms synchronized at the L1 stage were exposed to growing concentrations of 2C-I and 25I-NBOMe. The animal survival rate and the putative effects of the drugs on C. elegans development and reproductive behavior were assessed after 24 h of exposure. A concentration-dependent decrease in animal survival was observed. 25I-NBOMe

SUBMITTER: Gil-Martins E 

PROVIDER: S-EPMC11988394 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature