Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in <i>Saccharomyces cerevisiae</i>.

ABSTRACT: The discovery of histone H3 copper reductase activity provides a novel metabolic framework for understanding the functions of core histone residues, which, unlike N-terminal residues, have remained largely unexplored. We previously demonstrated that histone H3 cysteine 110 (H3C110) contributes to cupric (Cu²⁺) ion binding and its reduction to the cuprous (Cu¹⁺) form. However, this residue is absent in Saccharomyces cerevisiae, raising questions about its evolutionary and functional significance. Here, we report that H3C110 has been lost in many fungal lineages despite near-universal conservation across eukaryotes. Introduction of H3C110 into S. cerevisiae increased intracellular Cu¹⁺ levels and ameliorated the iron homeostasis defects caused b

SUBMITTER: Cheng C 

PROVIDER: S-EPMC11988410 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature