Control of morphogenesis during the <i>Staphylococcus aureus</i> cell cycle.

ABSTRACT: Bacterial cell division is a complex, multistage process requiring septum development while maintaining cell wall integrity. A dynamic, macromolecular protein complex, the divisome, tightly controls morphogenesis both spatially and temporally, but the mechanisms that tune septal progression are largely unknown. By studying conditional mutants of genes encoding DivIB, DivIC, and FtsL, an essential trimeric complex central to cell division in bacteria, we demonstrate that FtsL and DivIB play independent, hierarchical roles coordinating peptidoglycan synthesis across specific septal developmental checkpoints. They are required for the localization of downstream divisome components and the redistribution of peptidoglycan synthesis from the cell periphery to the septum. This is achieved by posi

SUBMITTER: Tinajero-Trejo M 

PROVIDER: S-EPMC11988411 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature