Differential Temperature-Induced Responses in Immortalized Oral and Skin Keratinocytes.

ABSTRACT: The epidermis of the skin and oral mucosa is constantly exposed to various environmental stimuli, including temperature changes. In particularly extreme conditions, such as excess heat or cold, significant injury may occur. Oral and skin keratinocytes exhibit tissue-specific differences in wound healing outcomes and the transcriptomic response to injury. This study investigated if skin and oral keratinocytes also have differential responses to heat- and cold-induced injury. Oral keratinocytes (TIGKs) were found to exhibit an enhanced viability following heat-induced injury compared to skin keratinocytes (HaCaTs). However, there were no discernible differences between skin and oral keratinocyte viability following cold-induced injury. To examine the transcriptomic differences between skin a

SUBMITTER: Han C 

PROVIDER: S-EPMC11988828 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature