Understanding of Benzophenone UV Absorber-Induced Damage and Apoptosis in Human Hepatoma Cells.

ABSTRACT: Benzophenone UV absorbers (BPs), a widely used family of organic UV absorbers (UVAs), have attracted considerable attention for their effects on organisms in recent years. Previous research has been unable to illuminate the intricate situation of BP pollution. To address this knowledge gap, we devised a BAPG-chain model that surpasses existing approaches based on biochemical detection, antioxidant defense systems, proteins, and genes to investigate the biological mechanisms of benzophenone-1 (BP-1) and benzophenone-3 (BP-3) within human hepatoma SMMC-7721 cells as model organisms. The BAPG-chain model links the cellular model, molecular level, macroscopic scale, and microscopic phenomena by adopting a global assessment mindset. Our findings indicate that BPs induce apoptosis via the excess

SUBMITTER: Tian L 

PROVIDER: S-EPMC11988835 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature