Transcriptome Analysis Reveals the Requirement of the TGFβ Pathway in Ascidian Tail Regression.

ABSTRACT: Metamorphosis is a common developmental process in invertebrate development. It is essential for the degeneration of larval organs, formation of adult organs, and adaptation transformation of the living environment. However, the underlying molecular regulatory mechanism remains to be elucidated. In this study, we used tail regression of ascidian Styela clava as a model to understand the gene regulation pathway and molecular mechanism in organ metamorphosis. The TGFβ signaling pathway was screened and demonstrated to be involved in tail regression based on RNA sequencing on the different larval stages and verification with inhibitor treatment experiments. We further investigated the downstream gene network of the TGFβ signaling pathway through comparative transcriptome data analysis

SUBMITTER: Shi W 

PROVIDER: S-EPMC11988888 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature