Synaptic basis of feature selectivity in hippocampal neurons.

ABSTRACT: A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals¹. Hippocampal CA1 pyramidal neurons display one of the most striking forms of feature selectivity by forming spatially and contextually selective receptive fields called place fields, which serve as a model for studying the synaptic basis of learning and memory. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence of place fields. However, despite decades of work, our understanding of how synaptic plasticity underlies place-field formation and memory encoding remains limited, largely due to a shortage of tools and technical challenges associated with the visualization of synaptic plasticity at the single-neuron re

SUBMITTER: Gonzalez KC 

PROVIDER: S-EPMC11988941 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature