Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules.

ABSTRACT: Short peptide sequences that are able to transport molecules across the cell membrane have been developed as tools for intracellular delivery of therapeutic molecules. This work describes a novel family of cell-penetrating peptides named Vectocell peptides [also termed DPVs (Diatos peptide vectors)]. These peptides, originating from human heparin binding proteins and/or anti-DNA antibodies, once conjugated to a therapeutic molecule, can deliver the molecule to either the cytoplasm or the nucleus of mammalian cells. Vectocell peptides can drive intracellular delivery of molecules of varying molecular mass, including full-length active immunoglobulins, with efficiency often greater than that of the well-characterized cell-penetrating peptide Tat. The internalization of Vectocell peptides has

SUBMITTER: De Coupade C 

PROVIDER: S-EPMC1198920 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature