Routine CT Diagnostics Cause Dose-Dependent Gene Expression Changes in Peripheral Blood Cells.

ABSTRACT: The increasing use of computed tomography (CT) has led to a rise in cumulative radiation dose due to medical imaging, raising concerns about potential long-term adverse effects. Large-scale epidemiological studies indicate a higher tumor incidence associated with CT examinations, but the underlying biological mechanisms remain largely unexplained. To gain further insights into the cellular response triggered by routine CT diagnostics, we investigated CT-induced changes of gene expression in peripheral blood cells using whole transcriptome sequencing. RNA was isolated from peripheral blood cells of 40 male patients with asymptomatic microhematuria, sampled before and after multi-phase abdominal CT (CTDIvol: 3.75-26.95 mGy, median: 6.55 mGy). On average, 22.11 million sequence reads (SD 5.71

SUBMITTER: Kaatsch HL 

PROVIDER: S-EPMC11989232 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature