Exploring Multi-Target Therapeutic Strategies for Glioblastoma via Endogenous Network Modeling.

ABSTRACT: Medical treatment of glioblastoma presents a significant challenge. A conventional medication has limited effectiveness, and a single-target therapy is usually effective only in the early stage of the treatment. Recently, there has been increasing focus on multi-target therapies, but the vast range of possible combinations makes clinical experimentation and implementation difficult. From the perspective of systems biology, this study conducted simulations for multi-target glioblastoma therapy based on dynamic analysis of previously established endogenous networks, validated with glioblastoma single-cell RNA sequencing data. Several potentially effective target combinations were identified. The findings also highlight the necessity of multi-target rather than single-target intervention stra

SUBMITTER: Yao M 

PROVIDER: S-EPMC11989339 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature