Antimicrobial, Quorum Sensing Inhibition, and Anti-Cancer Activities of Silver Nanoparticles Synthesized from Kenyan Bacterial Endophytes of <i>Teclea nobilis</i>.

ABSTRACT: Untapped bioactive compounds from microbial endophytes offer a promising solution to counter antimicrobial and chemotherapeutic drug resistance when complexed as silver nanoparticles (AgNPs). AgNPs were biosynthesized using cell-free supernatants from endophytic Streptomyces sp. KE4D and Bacillus safensis KE4K isolated from the Kenyan medicinal plant Teclea nobilis, following fermentation in three different media. Bacterial extracts were analyzed using gas chromatography-mass spectrometry. AgNPs were characterized using Fourier-transform infrared spectroscopy and high-resolution transmission electron microscopy. Antimicrobial activity was assessed using agar well diffusion assays, and quorum sensing inhibition (QSI) was investigated using Chromobacterium violaceum</

SUBMITTER: Mohamed F 

PROVIDER: S-EPMC11989699 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature