Transcriptomic Analysis of <i>Campylobacter jejuni</i> Following Exposure to Gaseous Chlorine Dioxide Reveals an Oxidative Stress Response.

ABSTRACT: Gaseous chlorine dioxide (ClO₂) is a potent antimicrobial agent used to control microbial contamination in food and water. This study evaluates the bactericidal activity of gaseous ClO₂ released from a sodium chlorite (NaClO₂) pad against Campylobacter jejuni. Exposure to a low concentration (0.4 mg/L) of dissolved ClO₂ for 2 h resulted in a >93% reduction of C. jejuni, highlighting the bacterium's extreme sensitivity to gaseous ClO₂. To elucidate the molecular mechanism of ClO₂-induced bactericidal action, transcriptomic analysis was conducted using RNA sequencing (RNA-seq). The results indicate that C. jejuni responds to ClO₂-induced oxidative stress by upregulating genes involved in reactiv

SUBMITTER: Dykes GE 

PROVIDER: S-EPMC11989795 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature