ROS-Responsive Fluorinated Oxalate Nanomedicine for Dual Chemiluminescence/¹⁹F MRI Imaging and Targeted Drug Release.

ABSTRACT: In this study, we developed a novel theranostic nanomedicine formulation that integrates multimodal imaging with controlled drug release in reactive oxygen species (ROS)-rich microenvironments. A fluorinated oxalate compound (FOC) was synthesized through a one-step condensation reaction between 1,1,1,3,3,3-hexafluoro-2-propanol and oxalyl chloride, characterized by ¹H, ¹³C, and ¹⁹F NMR spectroscopy. The FOC and luminophore-incorporated nanomedicine formulations reacted rapidly with hydrogen peroxide via the peroxyoxalate chemiluminescence (POCL) mechanism, producing strong chemiluminescence and inducing a notable 19-fold increase in ratiometric ¹⁹F NMR signal upon conversion to fluorinated alcohol (FAH), demonstrating promising potential for high

SUBMITTER: Peshkov A 

PROVIDER: S-EPMC11989819 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature