Shaping Outcomes: Levodopa-Carbidopa Intestinal Gel Treatment and Nutrition in Parkinson's Disease-A Prospective Observational Cohort Study.

ABSTRACT: Background/Objectives: Parkinson's Disease (PD) is a neurodegenerative disorder resulting in bradykinesia, rigidity and tremor, as well as numerous non-motor symptoms. Malnutrition in PD is correlated with levodopa-induced dyskinesia, decreased food intake, gastrointestinal symptoms and neurodegenerative processes. With disease progression, oral levodopa treatment becomes insufficient. One of the therapies used in advanced PD is levodopa-carbidopa intestinal gel. Its effect on the weight and nutrition of PD patients is poorly understood. The aim of this prospective single-center observational cohort study was to assess the effect of this treatment on weight, body composition and biochemical parameter changes over a two-year-long observation. The mood, cognition and motor status of t

SUBMITTER: Figura M 

PROVIDER: S-EPMC11989982 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature