Essential Oil of <i>Lippia origanoides</i> Kunth: Nanoformulation, Anticholinesterase Activity, and Molecular Docking.

ABSTRACT: This study investigates the therapeutic potential of Lippia origanoides essential oil (LOEO) in neurological and pharmaceutical applications. The chemical composition of LOEO was analyzed using gas chromatography-mass spectrometry (GC-MS), revealing major constituents, such as carvacrol, thymol, and γ-gurjunene, known for their antioxidant and antimicrobial properties. LOEO demonstrated significant acetylcholinesterase (AChE)-inhibitory activity, particularly in a nanoformulation that enhances bioavailability and stability. Additionally, the major constituent carvacrol, when tested in isolation, also exhibited AChE-inhibitory activity comparable to that of the nanoformulation. Molecular docking analysis indicated strong binding affinities between LOEO compounds and AChE, supporting

SUBMITTER: Junior AQDS 

PROVIDER: S-EPMC11990080 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature