Polyketides with Cardioprotective Bioactivities from Sponge-Associated Fungus <i>Aspergillus giganteus</i> MA46-5.

ABSTRACT: One pair of novel enantiomers, gigantdioxin A (+)-1 and B (-)-1, with a skeleton of benzo[d][1,3]dioxin; a new acetophenone gigantone A (3); a known 3-chlorogentisyl alcohol (2), which is the bioprecursor of 1; acetophenone (4); and chromone derivative (5) were obtained from the sponge-associated fungus Aspergillus giganteus MA46-5. Their structures were established by extensive and in-depth spectral analysis, such as UV, 1D and 2D NMR, and HRESIMS. The absolute configurations of (±)-1 were deduced by ORD, chiral separation, and experimental and computational ECD. Meanwhile, we proposed a possible biosynthetic pathway of (±)-1. Fortunately, the pathway was proved by biomimetic synthesis through 2, as a biop

SUBMITTER: Lin YT 

PROVIDER: S-EPMC11990167 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature