Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666.

ABSTRACT: Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (1) and D (2) were isolated from the marine-derived fungus Aspergillus sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (1 and 2) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (2) in this work.

SUBMITTER: Jiao F 

PROVIDER: S-EPMC11990187 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature