Circadian Regulation of Vitamin D Target Genes Reveals a Network Shaped by Individual Responsiveness.

ABSTRACT:

Background

In humans, vitamin D₃ synthesis follows a day-night rhythm due to its UV-B-dependent production.

Results

As part of the VitDHiD intervention study, we identified 87 in vivo vitamin D target genes with circadian expression patterns in immune cells, forming a regulatory network centered on transcription factors and membrane receptors. These genes exhibit a narrow basal expression range, with 80% downregulated upon vitamin D₃ supplementation. Clustering analysis revealed six distinct gene groups, with the two most prominent clusters driven by the transcription factor CSRNP1 (cysteine- and serine-rich nuclear protein 1) and GAS7 (growth arrest-specific 7), a known differentiation inducer. Among the 25 VitDHiD study participants, we identified two

SUBMITTER: Maissan P 

PROVIDER: S-EPMC11990303 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature